Officers were called to a report of an attempted burglary in Oakdale Road, Carlton, at around 11.35pm on Tuesday night.
The four suspects had fled the scene but, on arrival, officers discovered a large quantity of cannabis plants.
The plants, which total more than 500, will be dismantled today. Officers were assisted by the police helicopter and fire service.
A 24-year-old man and a 25-year-old man have been arrested on suspicion of cannabis cultivation.